Pharmacokinetics and tolerance of Gd | 化學工廠資訊網
由AChachuat著作·1992·被引用26次—TheaimofthisstudywastoassessthepharmacokineticsandtoleranceofGd-DOTA(DOTAREM)innon-dialysedpatientswithchronicrenalfailure.Eightpati.
The aim of this study was to assess the pharmacokinetics and tolerance of Gd-DOTA (DOTAREM) in non-dialysed patients with chronic renal failure. Eight patients with chronic renal failure (creatinine clearance between 10 and 60 ml/min) and four healthy volunteers were given i.v. Gd-DOTA (0.1 mmol/kg). Blood and urine samples were collected. Gd-DOTA tolerance was also studied (vital signs, biological parameters, adverse reactions). In healthy volunteers, Gd-DOTA was rapidly distributed in the extracellular space and almost totally eliminated in the urine (glomerular filtration, 93.3±4.7% of the dose 24 h post injection). In patients with chronic renal failure, a delayed and almost total urinary elimination observed with a correlation between Gd-DOTA clearance and plasma creatinine clearance (r = 0.964). Tolerance was good with no significant modification of renal function or other parameters. These results confirm pre...
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