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Charles Darwin, British Naturalist and Geologist
TDP (TAR DNA binding protein)-43 is an important target in neurodegeneration research, but its story started with the Human Immunodeficiency Virus (HIV) in the mid-1990s — it was shown to bind DNA motifs of HIV origin1; however, only a dozen more publications followed in the next decade.
In 2006, findings published in the journal Science2 would ultimately change TDP-43s status from a minor research target to a mainstay of neurodegeneration research. The authors identified TDP-43 as the mystery constituent of protein inclusions in FTLD-U, one of the most common forms of frontotemporal dementia (FTD), a family of neurodegenerative diseases.
Moreover, they identified it in the overlapping d...
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